Arpp21^em1Vihe
Endonuclease-mediated Allele Detail

Summary

• Symbol: Arpp21^em1Vihe
• Name: cyclic AMP-regulated phosphoprotein, 21; endonuclease-mediated mutation 1, Vigo Heissmeyer
• MGI ID: MGI:7852715
• Gene: Arpp21 Location: Chr9:111894159-112065006 bp, - strand Genetic Position: Chr9, 62.46 cM
• Alliance: Arpp21^em1Vihe page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs resulted in the deletion in exon 5 causing a frame-shift in the open reading frame of the long isoform. Increased expression of the short isoform was detected in thymocytes. (J:360918)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arpp21 Mutation: 56 strains or lines available

References

• Original: J:360918 Xu M, et al., The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression. Nat Commun. 2024 Mar 11;15(1):2194
• All: 1 reference(s)