Ifih1^tm2Draw
Targeted Allele Detail

Summary

• Symbol: Ifih1^tm2Draw
• Name: interferon induced with helicase C domain 1; targeted mutation 2, David Rawlings
• MGI ID: MGI:7852671
• Synonyms: Ifih1^R
• Gene: Ifih1 Location: Chr2:62426142-62476599 bp, - strand Genetic Position: Chr2, 35.85 cM, cytoband C3
• Alliance: Ifih1^tm2Draw page

Mutation origin

• Strain of Origin: NOD/ShiLtJ

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence)
• Mutation: Insertion
• Mutation details: A loxP site was inserted at position 47703, a mutated exon 15 with an A947T mutation (GCA to ACA) was introduced and an FRT flanked neo cassette and loxP site were inserted at position 50710 via homologous recombination. This mutation mimics the human type 1 diabetes risk allele. (J:360914)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ifih1 Mutation: 50 strains or lines available

References

• Original: J:360914 Stock AJ, et al., The IFIH1-A946T risk variant promotes diabetes in a sex-dependent manner. Front Immunol. 2024;15:1349601
• All: 1 reference(s)