Cav1^tm2.1Mle
Targeted Allele Detail

Summary

• Symbol: Cav1^tm2.1Mle
• Name: caveolin 1, caveolae protein; targeted mutation 2.1, Michael P Lisanti
• MGI ID: MGI:7840441
• Synonyms: CAV1^flox
• Gene: Cav1 Location: Chr6:17306387-17341323 bp, + strand Genetic Position: Chr6, 7.73 cM, cytoband A2
• Alliance: Cav1^tm2.1Mle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:345600
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector was designed to insert loxP sites flanking exon 3 of the caveolin 1, caveolae protein (Cav1) gene. The targeting construct also included an FRT-flanked neomycin cassette. The FRT-flanked neomycin cassette was removed by transient expression of FLP recombinase. (J:101977, J:345600)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cav1 Mutation: 33 strains or lines available

References

• Original: J:345600 Wolfe AR, et al., Nutrient scavenging-fueled growth in pancreatic cancer depends on caveolae-mediated endocytosis under nutrient-deprived conditions. Sci Adv. 2024 Mar;10(9):eadj3551
• All: 2 reference(s)