Mir219a-1^tm1.1Qrlu
Targeted Allele Detail

Summary

• Symbol: Mir219a-1^tm1.1Qrlu
• Name: microRNA 219a-1; targeted mutation 1.1, Q Richard Lu
• MGI ID: MGI:7834487
• Synonyms: miR-219-1^-
• Gene: Mir219a-1 Location: Chr17:34243957-34244066 bp, - strand Genetic Position: Chr17, 17.98 cM
• Alliance: Mir219a-1^tm1.1Qrlu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240024
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site in 5' of the coding exon followed by FRT-flanked neo cassette and a second loxP site after the coding exon in 3' were inserted to flank the Mir219a-1 gene. The Cre recombinase was removed by floxed coding sequence and the FRT-flanked neo cassette. It is a null allele. (J:240024)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir219a-1 Mutation: 2 strains or lines available

References

• Original: J:240024 Wang H, et al., miR-219 Cooperates with miR-338 in Myelination and Promotes Myelin Repair in the CNS. Dev Cell. 2017 Mar 27;40(6):566-582.e5
• All: 1 reference(s)