Cnn1^em1Mork
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cnn1^em1Mork
• Name: calponin 1; endonuclease-mediated mutation 1, Kathleen G Morgan
• MGI ID: MGI:7797876
• Gene: Cnn1 Location: Chr9:22010501-22020517 bp, + strand Genetic Position: Chr9, 8.3 cM, cytoband A2-A4
• Alliance: Cnn1^em1Mork page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutation: Single point mutation
• Mutation details: CRISPR/cas9 mediated recombination using a single guide RNA created a C to G transversion in the first base of the intronic CArG box that disrupts SRF binding. Expression analysis indicates partial loss of expression in visceral smooth muscle containing tissues but full loss of expression in the aorta (J:360267)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnn1 Mutation: 17 strains or lines available

References

• Original: J:360267 Kajuluri LP, et al., Calponin 1 inhibits agonist-induced ERK activation and decreases calcium sensitization in vascular smooth muscle. J Cell Mol Med. 2024 Jan;28(1):e18025
• All: 1 reference(s)