Ido1^tm1.2Rhmc
Targeted Allele Detail

Summary

• Symbol: Ido1^tm1.2Rhmc
• Name: indoleamine 2,3-dioxygenase 1; targeted mutation 1.2, Robert H McCusker
• MGI ID: MGI:7797864
• Synonyms: Ido1^TK
• Gene: Ido1 Location: Chr8:25074148-25086987 bp, - strand Genetic Position: Chr8, 12.76 cM
• Alliance: Ido1^tm1.2Rhmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:355685
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted 5' of the second exon and a second loxP was inserted 3' of the fourth exon. An frt-flanked neomycin selection cassette was removed via flp-mediated recombination and the loxP-flanked region was removed via cre-mediated recombination in the germline. (J:355685)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ido1 Mutation: 27 strains or lines available

References

• Original: J:355685 Wetzel LA, et al., Deletion of indoleamine 2,3 dioxygenase (Ido)1 but not Ido2 exacerbates disease symptoms of MOG(35-55)-induced experimental autoimmune encephalomyelitis. Brain Behav Immun Health. 2020 Aug;7:100116
• All: 1 reference(s)