Pdcd1^tm2.1Hon
Targeted Allele Detail

Summary

• Symbol: Pdcd1^tm2.1Hon
• Name: programmed cell death 1; targeted mutation 2.1, Tasuku Honjo
• MGI ID: MGI:7797829
• Synonyms: Pdcd1^fl
• Gene: Pdcd1 Location: Chr1:93966027-93980278 bp, - strand Genetic Position: Chr1, 47.47 cM
• Alliance: Pdcd1^tm2.1Hon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:360155
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6NJcl

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exons 2 and 3, and an frt-flanked neomycin selection cassette was inserted downstream of exon 3. The selection cassette was removed via FLP-mediated recombination in the germline. (J:360155)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdcd1 Mutation: 48 strains or lines available

Notes

HK3i embryonic stem cells (ESCs) derived from C57BL/6NJcl mice were used to generate the mice.

References

• Original: J:360155 Ogishi M, et al., Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling. Immunity. 2024 Dec 10;57(12):2790-2807.e15
• All: 1 reference(s)