Del(3Rr61-Rr406700)1.1Jcob
Targeted Allele Detail

Summary

• Symbol: Del(3Rr61-Rr406700)1.1Jcob
• Name: deletion, Chr 3, John Cobb 1.1
• MGI ID: MGI:7797764
• Synonyms: Del(3hs1262-hs1251)2Mostr
• Gene: Del(3Rr61-Rr406700)1.1Jcob Location: unknown Genetic Position: Chr3, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:355648
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutation: Intergenic deletion
• Del(3Rr61-Rr406700)1.1Jcob involves 2 genes/genome features (Rr406700, Rr61) View all
• Mutation details: The targeting vector replaced the LHB enhancer (hs1262-hs1251) region located 44.6 kb downstream of the Shox2 transcription start site with a floxed neomycin resistance cassette (mm10, chr3:66934220-66940095). Cre-mediated recombination removed the selection cassette. (J:355648)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(3Rr61-Rr406700)1.1Jcob Mutation: 0 strains or lines available

References

• Original: J:355648 Abassah-Oppong S, et al., A gene desert required for regulatory control of pleiotropic Shox2 expression and embryonic survival. Nat Commun. 2024 Oct 10;15(1):8793
• All: 1 reference(s)