Fignl1^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Fignl1^tm1.1Ics
• Name: fidgetin-like 1; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:7791002
• Synonyms: Fignl1^fl
• Gene: Fignl1 Location: Chr11:11737431-11758962 bp, - strand Genetic Position: Chr11, 7.08 cM, cytoband A2
• Alliance: Fignl1^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:359005
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A EUCOMM targeting vector was used to create this knockout-first conditional-ready reporter allele. The vector places an FRT site, splice acceptor site, IRES, lacZ cassette, loxP site, neomycin resistance gene cassette, second FRT site and second loxP upstream of exon 3 and a third loxP site downstream of exon 3. Flp-mediated recombination removed the promoter-driven neomycin cassette and the inserted lacZ reporter sequence, leaving behind the loxP-flanked critical exon 3. (J:359005)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fignl1 Mutation: 60 strains or lines available

References

• Original: J:359005 Zainu A, et al., FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading. Nat Commun. 2024 Aug 15;15(1):7015
• All: 1 reference(s)