E2f5^tm1.1Eand
Targeted Allele Detail

Summary

• Symbol: E2f5^tm1.1Eand
• Name: E2F transcription factor 5; targeted mutation 1.1, Eran Andrechek
• MGI ID: MGI:7790962
• Synonyms: E2F5^flox
• Gene: E2f5 Location: Chr3:14643701-14671369 bp, + strand Genetic Position: Chr3, 3.1 cM
• Alliance: E2f5^tm1.1Eand page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:358932
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a second loxP site and TK-Neo selection cassette and third loxP site were inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette leaving exons 2-3 floxed. (J:358932)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any E2f5 Mutation: 13 strains or lines available

References

• Original: J:358932 To B, et al., Insight into mammary gland development and tumor progression in an E2F5 conditional knockout mouse model. Oncogene. 2024 Nov;43(46):3402-3415
• All: 1 reference(s)