Cdk5rap2^em1Yhs
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cdk5rap2^em1Yhs
• Name: CDK5 regulatory subunit associated protein 2; endonuclease-mediated mutation 1, Young Hoon Sung
• MGI ID: MGI:7790751
• Gene: Cdk5rap2 Location: Chr4:70135092-70328672 bp, - strand Genetic Position: Chr4, 35.92 cM, cytoband C2
• Alliance: Cdk5rap2^em1Yhs page

Mutation origin

• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology with gRNAs targeting introns 1 and 34 generated a deletion of 175 kb from exons 2-34. (J:359330)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk5rap2 Mutation: 87 strains or lines available

References

• Original: J:359330 Kang D, et al., Roles of Cep215/Cdk5rap2 in establishing testicular architecture for mouse male germ cell development. FASEB J. 2024 Nov 30;38(22):e70188
• All: 1 reference(s)