Rr586^em1Iku
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr586^em1Iku
• Name: regulatory region 586; endonuclease-mediated mutation 1, Koichi Ikuta
• MGI ID: MGI:7790518
• Synonyms: CNS9-RORmut
• Gene: Rr586 Location: unknown Genetic Position: Chr15, Syntenic
• Alliance: Rr586^em1Iku page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Nucleotide substitutions
• Mutation details: Il7r enhancer CNS9, containing a retinoic acid receptor-related orphan receptor (ROR)-responsive element (RORE), located in intron 2, was targeted using crRNAs, tracrRNA and an ssODN template with CRISPR/Cas9 technology, resulting in the mutation of the core binding site from AGGTC to CCGTG. (J:359660)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr586 Mutation: 0 strains or lines available

References

• Original: J:359660 Tani-Ichi S, et al., A RORE-dependent Intronic Enhancer in the IL-7 Receptor-alpha Locus Controls Glucose Metabolism via Vgamma4+ gammadeltaT17 Cells. J Immunol. 2024 Aug 1;213(3):283-295
• All: 1 reference(s)