Slc4a5^em1Brsk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc4a5^em1Brsk
• Name: solute carrier family 4, sodium bicarbonate cotransporter, member 5; endonuclease-mediated mutation 1, Botond Roska
• MGI ID: MGI:7789054
• Synonyms: Slc4a5^tm1
• Gene: Slc4a5 Location: Chr6:83196810-83281927 bp, + strand Genetic Position: Chr6, 35.94 cM
• Alliance: Slc4a5^em1Brsk page

Mutation origin

• Strain of Origin: (C57BL/6J x BALB/c)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using CRISPR/Cas9 engineering, exon 3 of Slc4a5 (NM_001166067) was targeted with two antiparallel gRNAs to target the genomic sequence resulting in 201 bp insertion, 2 bp deletion and 7 bp insertion in exon 3 predicted to cause a premature stop codon before the first transmembrane regions. (J:358138)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc4a5 Mutation: 49 strains or lines available

References

• Original: J:358138 Morikawa R, et al., The sodium-bicarbonate cotransporter Slc4a5 mediates feedback at the first synapse of vision. Neuron. 2024 Sep 18
• All: 1 reference(s)