Slc26a4^em1Iroux
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc26a4^em1Iroux
• Name: solute carrier family 26, member 4; endonuclease-mediated mutation 1, Isabelle Roux
• MGI ID: MGI:7788447
• Synonyms: Slc26a4^HA
• Gene: Slc26a4 Location: Chr12:31569826-31609968 bp, - strand Genetic Position: Chr12, 13.53 cM, cytoband B1
• Alliance: Slc26a4^em1Iroux page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Epitope tag)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 genome editing technology was used to insert a single 27-bp HA tag coding sequence in between between codons 170, coding for amino-acid Ala, and 171, coding for Leu corresponding to genomic sequence chr12:31,547,936-31,547,935 (GRC m38/mm10) in exon 5 of the gene. (J:101977, J:359556)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc26a4 Mutation: 42 strains or lines available

References

• Original: J:359556 Lee HJ, et al., SLC26A4-AP-2 mu2 interaction regulates SLC26A4 plasma membrane abundance in the endolymphatic sac. Sci Adv. 2024 Oct 11;10(41):eadm8663
• All: 2 reference(s)