Gt(ROSA)26Sor^{tm14(G6pc1)Ics}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm14(G6pc1)Ics}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 14, Mouse Clinical Institute
• MGI ID: MGI:7788416
• Synonyms: Gt(ROSA)26Sor^{tm14(LSL-G6pc1)Ics}, Rosa26^{Stopcassette-lox-G6pc}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm14(G6pc1)Ics} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:359576
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The following elements were inserted into an intron: an adenovirus splice acceptor site, a conditional STOP cassette (loxP site flanked cassette consisting of PGK promoter, neomycin resistance gene, PGK and 3x SV40 p(A) signal sequences), followed by G6pc1 cDNA and bovine GH poly(A) signal sequence. This allele only expresses G6pc1 after Cre-mediated removal of the stop cassette. (J:359576)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1042 strains or lines available

References

• Original: J:359576 Estrada-Meza J, et al., Intestinal gluconeogenesis controls the neonatal development of hypothalamic feeding circuits. Mol Metab. 2024 Nov;89:102036
• All: 1 reference(s)