Zgrf1^em1Ucph
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zgrf1^em1Ucph
• Name: zinc finger, GRF-type containing 1; endonuclease-mediated mutation 1, University of Copenhagen
• MGI ID: MGI:7788097
• Gene: Zgrf1 Location: Chr3:127347138-127411672 bp, + strand Genetic Position: Chr3, 56.54 cM
• Alliance: Zgrf1^em1Ucph page
• IMPC: Zgrf1 gene page

Mutation origin

• Strain of Origin: C57BL/6N
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 4 produced a 5-base pair deletion, which is predicted to cause protein synthesis to terminate prematurely. Truncated in the middle of the DUF2439 domain, the putative peptide expressed from the mutated locus represents less than 2% of the ZGRF1 wild-type protein. (J:359381)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zgrf1 Mutation: 84 strains or lines available

References

• Original: J:359381 Lim EWK Kompocholi S, et al., Mouse ZGRF1 helicase facilitates DNA repair and maintains efficient fertility. MGI Direct Data Submission. 2024
• All: 1 reference(s)