Cftr^em5Cwr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cftr^em5Cwr
• Name: cystic fibrosis transmembrane conductance regulator; endonuclease-mediated mutation 5, Case Western Reserve University
• MGI ID: MGI:7786762
• Synonyms: Cftr^W1282X
• Gene: Cftr Location: Chr6:18170686-18322767 bp, + strand Genetic Position: Chr6, 8.1 cM, cytoband A3
• Alliance: Cftr^em5Cwr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 genome editing technology was used to introduce a G to A nucleotide alteration, changing the tryptophan at amino acid 1282 to a stop codon (W1282X). (J:359282)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cftr Mutation: 97 strains or lines available

References

• Original: J:359282 Michicich M, et al., A W1282X cystic fibrosis mouse allows the study of pharmacological and gene-editing therapeutics to restore CFTR function. J Cyst Fibros. 2024 Nov 11
• All: 1 reference(s)