Cftr^em9Cwr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cftr^em9Cwr
• Name: cystic fibrosis transmembrane conductance regulator; endonuclease-mediated mutation 9, Case Western Reserve University
• MGI ID: MGI:7786761
• Synonyms: R553X CF
• Gene: Cftr Location: Chr6:18170686-18322767 bp, + strand Genetic Position: Chr6, 8.1 cM, cytoband A3
• Alliance: Cftr^em9Cwr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 genome editing technology was used to replace mouse exon 12 and flanking intronic sequences (130 bp upstream; 89 bp downstream) with the corresponding human sequence exon 12 containing the R553X mutation. (J:359278)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cftr Mutation: 97 strains or lines available

References

• Original: J:359278 Sun Y, et al., In vivo editing of lung stem cells for durable gene correction in mice. Science. 2024 Jun 14;384(6701):1196-1202
• All: 1 reference(s)