Khdrbs3^em1Schei
Endonuclease-mediated Allele Detail

Summary

• Symbol: Khdrbs3^em1Schei
• Name: KH domain containing, RNA binding, signal transduction associated 3; endonuclease-mediated mutation 1, Peter Scheiffele
• MGI ID: MGI:7785284
• Synonyms: Slm2 MT
• Gene: Khdrbs3 Location: Chr15:68800269-68973060 bp, + strand Genetic Position: Chr15, 30.36 cM
• Alliance: Khdrbs3^em1Schei page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate an in-frame deletion in exon 1. These mice express a protein that lacks a first QUA domain, which results in a significant reduction in activity toward alternative splicing of target genes. (J:314864)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Khdrbs3 Mutation: 25 strains or lines available

References

• Original: J:314864 Iijima Y, et al., SAM68-Specific Splicing Is Required for Proper Selection of Alternative 3' UTR Isoforms in the Nervous System. iScience. 2019 Dec 20;22:318-335
• All: 1 reference(s)