Camk2d^em1Eno
Endonuclease-mediated Allele Detail

Summary

• Symbol: Camk2d^em1Eno
• Name: calcium/calmodulin-dependent protein kinase II, delta; endonuclease-mediated mutation 1, Eric N Olson
• MGI ID: MGI:7785179
• Synonyms: T287A
• Gene: Camk2d Location: Chr3:126389951-126639975 bp, + strand Genetic Position: Chr3, 55.97 cM
• Alliance: Camk2d^em1Eno page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas9 technology generated an A to G change at position 859 (c.A859G) resulting in a threonine to alanine substitution at amino acid 287 (p.T287A). This mutation makes Camk2d resistant to autophosphorylation. (J:358926)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Camk2d Mutation: 44 strains or lines available

References

• Original: J:358926 Lebek S, et al., Elimination of CaMKIIdelta Autophosphorylation by CRISPR-Cas9 Base Editing Improves Survival and Cardiac Function in Heart Failure in Mice. Circulation. 2023 Nov 7;148(19):1490-1504
• All: 1 reference(s)