Tg(CAG-YAP1*)1Jfm
Transgene Detail

Summary

• Symbol: Tg(CAG-YAP1*)1Jfm
• Name: transgene insertion 1, James F. Martin
• MGI ID: MGI:7782579
• Synonyms: Tg[Jojo-Flag::YAP5SA]5JFM, YAP5SA
• Transgene: Tg(CAG-YAP1*)1Jfm Location: unknown
• Alliance: Tg(CAG-YAP1*)1Jfm page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-YAP1*)1Jfm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  YAP1 (10413)

  Yap1	(MGI:103262)

  variant with eight serine (S) residues mutated to alanine (A) at the five canonical Lats-dependent phosphorylation motifs (YAP5SA, S61A, S109A, S127A, S128A, S131A, S163A, S164A, and S381A)

• Tg(CAG-YAP1*)1Jfm expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  chicken	CAG

• Mutation details: This transgene consists of a CAG promoter, a loxP-flanked eGFP-STOP cassette, a FLAG-tagged human YAP1 variant with eight serine (S) residues mutated to alanine (A) at the five canonical Lats-dependent phosphorylation motifs (YAP5SA, S61A, S109A, S127A, S128A, S131A, S163A, S164A, and S381A),and and IRES-LacZ reporter for lineage tracing. EGFP is expressed in embryonic and postnatal hearts before Cre recombination, and lacZ after recombination. (J:280849)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:280849 Monroe TO, et al., YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo. Dev Cell. 2019 Mar 25;48(6):765-779.e7
• All: 2 reference(s)