Cux1^tm1.1Wzac
Targeted Allele Detail

Summary

• Symbol: Cux1^tm1.1Wzac
• Name: cut-like homeobox 1; targeted mutation 1.1, William J Zacharias
• MGI ID: MGI:7782520
• Synonyms: Cux1^fl
• Gene: Cux1 Location: Chr5:136276989-136596344 bp, - strand Genetic Position: Chr5, 75.96 cM
• Alliance: Cux1^tm1.1Wzac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:358491
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, Epitope tag)
• Mutation: Insertion
• Mutation details: A targeting construct composed of an initial loxP site upstream of exon 22 of the cut-like homeobox 1 (Cux1) gene, followed by a second loxP site in intron 23, and an HA-tag inserted at the 3' end of exon 24. The targeting construct also included an FRT-flanked neomycin and hygromycin cassettes. The FRT-flanked neomycin was removed by a Flp-recombinase. (J:358491)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cux1 Mutation: 116 strains or lines available

References

• Original: J:358491 Zhao B, et al., The homeobox transcription factor Cux1 coordinates postnatal epithelial developmental timing but is dispensable for lung organogenesis and regeneration. bioRxiv. 2024
• All: 1 reference(s)