Wdr5^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Wdr5^tm1.1Ics
• Name: WD repeat domain 5; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:7781541
• Synonyms: Wdr5^fl
• Gene: Wdr5 Location: Chr2:27405169-27426547 bp, + strand Genetic Position: Chr2, 19.38 cM
• Alliance: Wdr5^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:252998
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and an FRT site flanked neomycin resistance gene cassette followed by a second loxP site were inserted into intron 4. The neo cassette was removed through subsequent Flp-mediated recombination, leaving a conditional-ready allele with exons 2-4 floxed. (J:252998)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wdr5 Mutation: 31 strains or lines available

References

• Original: J:252998 Vilhais-Neto GC, et al., The WHHERE coactivator complex is required for retinoic acid-dependent regulation of embryonic symmetry. Nat Commun. 2017 Sep 28;8(1):728
• All: 1 reference(s)