H2az1^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: H2az1^tm1.1Ics
• Name: H2A.Z variant histone 1; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:7781419
• Synonyms: H2A.Z-1^flox
• Gene: H2az1 Location: Chr3:137570248-137572683 bp, + strand Genetic Position: Chr3, 63.94 cM
• Alliance: H2az1^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:288671
• Parent Cell Line: S3 (ES Cell)
• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and a second loxP site and an FRT site flanked neomycin resistance gene cassette were inserted into intron 4. The neo cassette was removed through subsequent Flp-mediated recombination, leaving a conditional-ready allele with exons 2-4 floxed. (J:288671)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any H2az1 Mutation: 14 strains or lines available

References

• Original: J:288671 Belotti E, et al., H2A.Z is dispensable for both basal and activated transcription in post-mitotic mouse muscles. Nucleic Acids Res. 2020 May 21;48(9):4601-4613
• All: 2 reference(s)