Xylt1^tm1.1Moou
Targeted Allele Detail

Summary

• Symbol: Xylt1^tm1.1Moou
• Name: xylosyltransferase 1; targeted mutation 1.1, Mohamed Ouzzine
• MGI ID: MGI:7780060
• Synonyms: XylT-I/KO
• Gene: Xylt1 Location: Chr7:116980214-117266853 bp, + strand Genetic Position: Chr7, 62.93 cM
• Alliance: Xylt1^tm1.1Moou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:336752
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site flanked neomycin resistance gene cassette replaced exon 1 (and up- and downstream sequence). The neo cassette was removed through subsequent Cre-mediated recombination, resulting in an ~18.5 kb deletion. (J:336752)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xylt1 Mutation: 41 strains or lines available

References

• Original: J:336752 Taieb M, et al., Xylosyltransferase I mediates the synthesis of proteoglycans with long glycosaminoglycan chains and controls chondrocyte hypertrophy and collagen fibers organization of in the growth plate. Cell Death Dis. 2023 Jun 9;14(6):355
• All: 1 reference(s)