Xylt1^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Xylt1^tm1.1Ics
• Name: xylosyltransferase 1; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:7780058
• Synonyms: XylT1^flox
• Gene: Xylt1 Location: Chr7:116980214-117266853 bp, + strand Genetic Position: Chr7, 62.93 cM
• Alliance: Xylt1^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:336752
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 4 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 5. The neo cassette was removed through subsequent Flp-mediated recombination, leaving a conditional-ready allele with exon 5 floxed. (J:336752)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Xylt1 Mutation: 41 strains or lines available

References

• Original: J:336752 Taieb M, et al., Xylosyltransferase I mediates the synthesis of proteoglycans with long glycosaminoglycan chains and controls chondrocyte hypertrophy and collagen fibers organization of in the growth plate. Cell Death Dis. 2023 Jun 9;14(6):355
• All: 1 reference(s)