Tspan8^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Tspan8^tm1.1Ics
• Name: tetraspanin 8; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:7780043
• Gene: Tspan8 Location: Chr10:115652737-115685798 bp, + strand Genetic Position: Chr10, 63.51 cM
• Alliance: Tspan8^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:358255
• Parent Cell Line: S3 (ES Cell)
• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 2. The neo cassette was removed through subsequent Flp-mediated recombination, leaving a conditional-ready allele with exons 1 and 2 floxed. (J:358255)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tspan8 Mutation: 21 strains or lines available

References

• Original: J:358255 Zhu Y, et al., The Tetraspanin Tspan8 Associates with Endothelin Converting Enzyme ECE1 and Regulates Its Activity. Cancers (Basel). 2023 Sep 27;15(19)
• All: 1 reference(s)