Usp11^tm1.1Xhp
Targeted Allele Detail

Summary

• Symbol: Usp11^tm1.1Xhp
• Name: ubiquitin specific peptidase 11; targeted mutation 1.1, Xin-Hai Pei
• MGI ID: MGI:7779591
• Gene: Usp11 Location: ChrX:20570148-20586778 bp, + strand Genetic Position: ChrX, 16.2 cM
• Alliance: Usp11^tm1.1Xhp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:357577
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT-flanked PGK-neo and second loxP site were inserted downstream of exon 4. Exons 2-4 and the PGK-neo cassette were deleted via cre-mediated recombination in the germline. Western blot analysis confirmed the absence of protein in homozygotes. (J:357577)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp11 Mutation: 20 strains or lines available

References

• Original: J:357577 Qian T, et al., USP11 deubiquitinates E-cadherin and maintains the luminal fate of mammary tumor cells to suppress breast cancer. J Biol Chem. 2024 Sep 11;300(10):107768
• All: 1 reference(s)