Ptger3^tm1.1Csml
Targeted Allele Detail

Summary

• Symbol: Ptger3^tm1.1Csml
• Name: prostaglandin E receptor 3 (subtype EP3); targeted mutation 1.1, Clifford B Saper
• MGI ID: MGI:7768077
• Synonyms: EP3^-
• Gene: Ptger3 Location: Chr3:157272459-157350392 bp, + strand Genetic Position: Chr3, 81.32 cM
• Alliance: Ptger3^tm1.1Csml page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:331372
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was introduced 70 bp upstream of the translation initiation site and a loxP-frt-Neo/KanR-frt cassette was inserted 408 bp downstream of exon 1. The selectable markers were removed by flp-mediated recombination using transient flp expression. Exon 1 was deleted via cre-mediated recombination. (J:127396)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptger3 Mutation: 22 strains or lines available

References

• Original: J:331372 Tao X, et al., EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis model. J Exp Med. 2022 May 2;219(5):e20212414
• All: 2 reference(s)