Sox2^{tm2.1(rtTA)Rlb}
Targeted Allele Detail

Summary

• Symbol: Sox2^{tm2.1(rtTA)Rlb}
• Name: SRY (sex determining region Y)-box 2; targeted mutation 1, Robin Lovell-Badge
• MGI ID: MGI:7767929
• Synonyms: Sox2^2A-rtTA, Sox2^{tm1.1(RFP/rtTA)Rlb}
• Gene: Sox2 Location: Chr3:34704554-34706610 bp, + strand Genetic Position: Chr3, 16.93 cM, cytoband A2-B
• Alliance: Sox2^{tm2.1(rtTA)Rlb} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:357896
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Reporter, Transactivator)
• Mutation: Insertion
• Mutation details: A Sox2-T2A-TgRFP-T2A-rtTA cassette was inserted in the Sox2 locus by homologous recombination. The neomycin resistance selection cassette was removed. (J:357896)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox2 Mutation: 56 strains or lines available

References

• Original: J:357896 Sheridan D, et al., Gonadotrophs have a dual origin, with most derived from pituitary stem cells during minipuberty. bioRxiv. 2024
• All: 1 reference(s)