Rr428^em1Yzhou
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr428^em1Yzhou
• Name: regulatory region 428; endonuclease-mediated mutation 1, Yan Zhou
• MGI ID: MGI:7766962
• Synonyms: Ctnnb1^deltai.enh
• Gene: Rr428 Location: unknown Genetic Position: Chr9, Syntenic
• Alliance: Rr428^em1Yzhou page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutations: Intergenic deletion, Intragenic deletion
• Mutation details: The Ctnnb1 intestinal enhancer, located upstream of the gene, was targeted with sgRNAs using CRISPR/Cas9 technology, resulting in its deletion. (J:355476)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr428 Mutation: 0 strains or lines available

References

• Original: J:355476 Hua X, et al., A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia. Elife. 2024 Sep 25;13
• All: 1 reference(s)