Ndufb7^tm1.1Lrsn
Targeted Allele Detail

Summary

• Symbol: Ndufb7^tm1.1Lrsn
• Name: NADH:ubiquinone oxidoreductase subunit B7; targeted mutation 1.1, Nils-Goran Larsson
• MGI ID: MGI:7764978
• Gene: Ndufb7 Location: Chr8:84293387-84298252 bp, + strand Genetic Position: Chr8, 40.22 cM, cytoband C3
• Alliance: Ndufb7^tm1.1Lrsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:357794
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A construct containing a loxP site, FRT-flanked neo cassette, wild-type copies of exons 2 and 3, human growth hormone pA sequence, FRT flanked puro cassette, loxP site, wild-type exon 2 and mutant exon 3 lacking the last 60 nucleotides was inserted via homologous recombination. Flp-mediated recombination removed the selection cassettes. (J:357794)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ndufb7 Mutation: 12 strains or lines available

References

• Original: J:357794 Milenkovic D, et al., Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes. Cell Metab. 2023 Oct 3;35(10):1799-1813.e7
• All: 1 reference(s)