Ndufa11^tm1.1Lrsn
Targeted Allele Detail

Summary

• Symbol: Ndufa11^tm1.1Lrsn
• Name: NADH:ubiquinone oxidoreductase subunit A11; targeted mutation 1.1, Nils-Goran Larsson
• MGI ID: MGI:7764977
• Synonyms: Ndufa11^loxP
• Gene: Ndufa11 Location: Chr17:57024767-57029141 bp, + strand Genetic Position: Chr17, 29.47 cM, cytoband D
• Alliance: Ndufa11^tm1.1Lrsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:357794
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A construct containing a loxP site, FRT-flanked neo cassette, wild-type copy of exon 4, human growth hormone pA sequence, FRT flanked puro casette, loxP site, and mutant exon 4 with a Y110A substitution (TAT to GCA) was inserted via homologous recombination. Flp mediated recombination removed the selection cassettes. (J:357794)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ndufa11 Mutation: 17 strains or lines available

References

• Original: J:357794 Milenkovic D, et al., Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes. Cell Metab. 2023 Oct 3;35(10):1799-1813.e7
• All: 1 reference(s)