Yars1^tm1.1Xly
Targeted Allele Detail

Summary

• Symbol: Yars1^tm1.1Xly
• Name: tyrosyl-tRNA synthetase 1; targeted mutation 1.1, Xiang-Lei Yang
• MGI ID: MGI:7764500
• Synonyms: Yars^deltaNLS
• Gene: Yars1 Location: Chr4:129083595-129113033 bp, + strand Genetic Position: Chr4, 63.05 cM
• Alliance: Yars1^tm1.1Xly page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:357574
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Altered localization)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The nuclear localization signal in exon 7 was modified from KKKLKK to NNKLNK and an FRT-flanked neo cassette was inserted downstream of exon 7 via homologous recombination. Flp-mediated recombination removed the neo cassette. (J:357574)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Yars1 Mutation: 66 strains or lines available

References

• Original: J:357574 Jones JA, et al., Murine nuclear tyrosyl-tRNA synthetase deficiency leads to fat storage deficiency and hearing loss. J Biol Chem. 2024 Sep 12;300(10):107756
• All: 1 reference(s)