Rr406462^em1Ezk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr406462^em1Ezk
• Name: regulatory region 406462; endonuclease-mediated mutation 1, Evgeny Z Kvon
• MGI ID: MGI:7764491
• Synonyms: deltahs654
• Gene: Rr406462 Location: Chr9:90574863-90575976 bp, . strand Genetic Position: Chr9, Syntenic
• Alliance: Rr406462^em1Ezk page

Mutation origin

• Strain of Origin: FVB

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intergenic deletion
• Mutation details: The Zic1 and Zic4 midbrain enhancer was targeted using sgRNAs with CRISPR/Cas9 technology, resulting in its deletion (GRCm39:chr9:90570629-90585287). (J:347410)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr406462 Mutation: 0 strains or lines available

References

• Original: J:347410 Chen Z, et al., Increased enhancer-promoter interactions during developmental enhancer activation in mammals. Nat Genet. 2024 Apr;56(4):675-685
• All: 1 reference(s)