Isl2^{tm1.1(Efna3)Ics}
Targeted Allele Detail

Summary

• Symbol: Isl2^{tm1.1(Efna3)Ics}
• Name: insulin related protein 2 (islet 2); targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:7751204
• Synonyms: Efna3KI, Isl2^{tm1.1(IRES-Efna3-Sv40pA)Ics}
• Gene: Isl2 Location: Chr9:55445956-55453464 bp, + strand Genetic Position: Chr9, 30.13 cM, cytoband C
• Alliance: Isl2^{tm1.1(Efna3)Ics} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244080
• Parent Cell Line: S3 (ES Cell)
• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Isl2^{tm1.1(Efna3)Ics} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Efna3 (MGI:106644)

• Mutation details: IRES, mouse Efna3 cDNA and SV40 poly(A) signal sequences, followed by a loxP site flanked neomycin resistance gene cassette, were inserted into exon 6 after the stop codon. The neo cassette was removed through subsequent Cre-mediated recombination. (J:244080)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Isl2 Mutation: 28 strains or lines available

References

• Original: J:244080 Savier E, et al., A molecular mechanism for the topographic alignment of convergent neural maps. Elife. 2017 Mar 14;6:e20470
• All: 1 reference(s)