Mtr^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Mtr^tm1.1Ics
• Name: 5-methyltetrahydrofolate-homocysteine methyltransferase; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:7751203
• Synonyms: Mtr lox, Mtr^tm1.cICS
• Gene: Mtr Location: Chr13:12197598-12272999 bp, - strand Genetic Position: Chr13, 4.52 cM
• Alliance: Mtr^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:355615
• Parent Cell Line: S3 (ES Cell)
• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The allele was created using the PG00208_Z_2_E12 EUCOMM vector (used to create Mtr^{tm1a(KOMP)Mbp}) and the lacZ-neo cassette was removed through subsequent Flp-mediated recombination, leaving a conditional-ready allele with exons 4 and 5 (with reference to ENSMUST00000099856) floxed. (J:355615)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtr Mutation: 50 strains or lines available

References

• Original: J:355615 Hassan Z, et al., Cognitive Impairment Is Associated with AMPAR Glutamatergic Dysfunction in a Mouse Model of Neuronal Methionine Synthase Deficiency. Cells. 2023 Apr 27;12(9)
• All: 1 reference(s)