Pla2g6^tm1.1Otsu
Targeted Allele Detail

Summary

• Symbol: Pla2g6^tm1.1Otsu
• Name: phospholipase A2, group VI; targeted mutation 1.1, Kinya Otsu
• MGI ID: MGI:7750885
• Synonyms: Pla2g6^flox
• Gene: Pla2g6 Location: Chr15:79170428-79212590 bp, - strand Genetic Position: Chr15, 37.7 cM
• Alliance: Pla2g6^tm1.1Otsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:355453
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129 x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and FRT-flanked neo cassette was inserted upstream of exon 10 and a loxP site was inserted downstream of exon 10 via homologous recombination. Flp mediated recombination removed the neo cassette (J:355453)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pla2g6 Mutation: 67 strains or lines available

References

• Original: J:355453 Sugihara R, et al., Lysophosphatidylserine induces necrosis in pressure overloaded male mouse hearts via G protein coupled receptor 34. Nat Commun. 2023 Jul 31;14(1):4494
• All: 1 reference(s)