Cand1^{em3(CAG-Cand1)Zpan}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cand1^{em3(CAG-Cand1)Zpan}
• Name: cullin associated and neddylation disassociated 1; endonuclease-mediated mutation 3, Zhenwei Pan
• MGI ID: MGI:7750861
• Gene: Cand1 Location: Chr10:119035160-119075960 bp, - strand Genetic Position: Chr10, 67.08 cM, cytoband D2
• Alliance: Cand1^{em3(CAG-Cand1)Zpan} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Cand1^{em3(CAG-Cand1)Zpan} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cand1 (MGI:1261820)

• Cand1^{em3(CAG-Cand1)Zpan} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  chicken	CAG

• Mutation details: CRISPR/cas9 mediated recombination inserted a construct containing a CAG promoter, floxed pgk-neo gene, Kozak sequence, mouse Cand1 cds-rBG cassette downstream of exon 1. The allele allows for conditional overexpression of Cand1. (J:355450)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cand1 Mutation: 52 strains or lines available

References

• Original: J:355450 Huang X, et al., Cullin-associated and neddylation-dissociated protein 1 (CAND1) alleviates NAFLD by reducing ubiquitinated degradation of ACAA2. Nat Commun. 2023 Aug 1;14(1):4620
• All: 1 reference(s)