Cd53^em1Stplz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cd53^em1Stplz
• Name: CD53 antigen; endonuclease-mediated mutation 1, Laura Schuettpelz
• MGI ID: MGI:7738814
• Gene: Cd53 Location: Chr3:106667237-106697465 bp, - strand Genetic Position: Chr3, 46.53 cM
• Alliance: Cd53^em1Stplz page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/cas9-mediated recombination using guide RNAs targeting exon 3 created a 4bp deletion. (J:294321)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd53 Mutation: 21 strains or lines available

References

• Original: J:294321 Greenberg ZJ, et al., The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling. J Immunol. 2020 Jan 1;204(1):58-67
• All: 2 reference(s)