Eed^tm1.1Sho
Targeted Allele Detail

Summary

• Symbol: Eed^tm1.1Sho
• Name: embryonic ectoderm development; targeted mutation 1.1, Stuart Orkin
• MGI ID: MGI:7738502
• Gene: Eed Location: Chr7:89603862-89630184 bp, - strand Genetic Position: Chr7, 50.42 cM
• Alliance: Eed^tm1.1Sho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:355308
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 3, and an FRT-flanked neomycin resistance (neo) cassette was inserted between exons 6 and 7 followed immediately by a second loxP site. Cre-mediated recombination removed the floxed exons. (J:355308)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eed Mutation: 117 strains or lines available

References

• Original: J:355308 Du Z, et al., Stepwise de novo establishment of inactive X chromosome architecture in early development. Nat Genet. 2024 Sep 10
• All: 2 reference(s)