Myc^tm1.1Rne
Targeted Allele Detail

Summary

• Symbol: Myc^tm1.1Rne
• Name: Myc proto-oncogene, bHLH transcription factor; targeted mutation 1.1, Robert N Eisenman
• MGI ID: MGI:7737692
• Synonyms: Myc^T58A
• Gene: Myc Location: Chr15:61857240-61862223 bp, + strand Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
• Alliance: Myc^tm1.1Rne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:347772
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Insertion
• Mutation details: A T58A mutation in exon 2, disrupting phosphorylation at this site, was inserted along with a floxed pgk-neo cassette via homologous recombination. Cre mediated recombination removed the pgk-neo cassette. (J:347772)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myc Mutation: 42 strains or lines available

References

• Original: J:347772 Freie B, et al., A germline point mutation in the MYC-FBW7 phosphodegron initiates hematopoietic malignancies. Genes Dev. 2024 Apr 17;38(5-6):253-272
• All: 1 reference(s)