Rab12^em1Yue
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rab12^em1Yue
• Name: RAB12, member RAS oncogene family; endonuclease-mediated mutation 1, Zhenyu Yue
• MGI ID: MGI:7737635
• Synonyms: RAB12KO
• Gene: Rab12 Location: Chr17:66801507-66826712 bp, - strand Genetic Position: Chr17, 37.88 cM
• Alliance: Rab12^em1Yue page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• The exon 3 of the Rab12 gene was deleted in the C57BL/6J background using CRISPR-Cas9 technology. (J:354845)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rab12 Mutation: 19 strains or lines available

References

• Original: J:354845 Heaton GR, et al., Targeting Specific Kinase Substrates Rescues Increased Colitis Severity Induced by the Crohn's Disease-Linked LRRK2-N2081D Variant. bioRxiv. 2024 Sep 5
• All: 1 reference(s)