Rr246047^em1Nasp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr246047^em1Nasp
• Name: regulatory region 246047; endonuclease-mediated mutation 1, Navjot Singh Pabla
• MGI ID: MGI:7733418
• Synonyms: Sox9 Prom^mut
• Gene: Rr246047 Location: Chr11:112671200-112676801 bp Genetic Position: Chr11, Syntenic
• Alliance: Rr246047^em1Nasp page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Single point mutation
• Mutation details: The Sox9 promoter was targeted with an sgRNA and an ssODN template using CRISPR/Cas9 technology, resulting in changing Zfp24-binding site TCAT (GRCm39:chr11:112671045-112671048) to TAAT. (J:339773)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr246047 Mutation: 0 strains or lines available

References

• Original: J:339773 Kim JY, et al., Zinc finger protein 24-dependent transcription factor SOX9 up-regulation protects tubular epithelial cells during acute kidney injury. Kidney Int. 2023 Jun;103(6):1093-1104
• All: 1 reference(s)