Plcg2^tm1.1Smas
Targeted Allele Detail

Summary

• Symbol: Plcg2^tm1.1Smas
• Name: phospholipase C, gamma 2; targeted mutation 1.1, Seth Masters
• MGI ID: MGI:7720050
• Synonyms: Plcg2^S707Y
• Gene: Plcg2 Location: Chr8:118225030-118361881 bp, + strand Genetic Position: Chr8, 64.26 cM
• Alliance: Plcg2^tm1.1Smas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:354091
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: An FRT flanked neo cassette was inserted upstream of exon 22 and an S707Y mutation was inserted in exon 22 via homologous recombination. Flp mediated recombination removed the neo cassette. This mutation is homologous to one in human APLAID patients. (J:354091)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcg2 Mutation: 73 strains or lines available

References

• Original: J:354091 Mulazzani E, et al., G-CSF drives autoinflammation in APLAID. Nat Immunol. 2023 May;24(5):814-826
• All: 1 reference(s)