Fto^em1Yqt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fto^em1Yqt
• Name: FTO alpha-ketoglutarate dependent dioxygenase; endonuclease-mediated mutation 1, Yue-Qiu Tan
• MGI ID: MGI:7718677
• Gene: Fto Location: Chr8:92040153-92395067 bp, + strand Genetic Position: Chr8, 44.34 cM
• Alliance: Fto^em1Yqt page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRIPSR/cas9 mediated recombination using guide RNAs targeting exon 3 created a 4 bp deletion. (J:353888)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fto Mutation: 76 strains or lines available

References

• Original: J:353888 Wu Y, et al., Fat mass and obesity-associated factor (FTO)-mediated N6-methyladenosine regulates spermatogenesis in an age-dependent manner. J Biol Chem. 2023 May 3;299(6):104783
• All: 1 reference(s)