Zfp36l1^tm2.1Pjb
Targeted Allele Detail

Summary

• Symbol: Zfp36l1^tm2.1Pjb
• Name: zinc finger protein 36, C3H type-like 1; targeted mutation 2.1, Perry J Blackshear
• MGI ID: MGI:7716936
• Gene: Zfp36l1 Location: Chr12:80154534-80159787 bp, - strand Genetic Position: Chr12, 36.46 cM
• Alliance: Zfp36l1^tm2.1Pjb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223460
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector was designed to insert one loxP site upstream of exon 2 and a loxP-flanked neomycin cassette downstream of exon 2 of the zinc finger protein 36, C3H type-like 1 (Zfp36l1) locus on chromosome 12. The construct was electroporated into C57BL/6-derived embryonic stem cells (Xenogen). The neo cassette was removed by the electroporation of cre recombinase into the correctly targeted ES cells. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zfp36l1 Mutation: 10 strains or lines available

References

• Original: J:223460 Hyatt LD, et al., Myeloid ZFP36L1 does not regulate inflammation or host defense in mouse models of acute bacterial infection. PLoS One. 2014;9(10):e109072
• All: 3 reference(s)