Ms4a7^em1Xiaow
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ms4a7^em1Xiaow
• Name: membrane-spanning 4-domains, subfamily A, member 7; endonuclease-mediated mutation 1, Xiaoxiao Wan
• MGI ID: MGI:7716929
• Synonyms: Ms4a7^-
• Gene: Ms4a7 Location: Chr19:11298403-11313510 bp, - strand Genetic Position: Chr19, 8.43 cM, cytoband B
• Alliance: Ms4a7^em1Xiaow page

Mutation origin

• Strain of Origin: NOD/ShiLtJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• A 11 bp deletion in exon 3 in the Ms4a7 gene was generated by CRISPR/Cas9 on the NOD background. (J:349428)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ms4a7 Mutation: 14 strains or lines available

References

• Original: J:349428 Srivastava N, et al., CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8(+) T cells in diabetic autoimmunity. Immunity. 2024 May 6
• All: 1 reference(s)