Peli3^tm1.1Shp
Targeted Allele Detail

Summary

• Symbol: Peli3^tm1.1Shp
• Name: pellino 3; targeted mutation 1.1, Seok Hee Park
• MGI ID: MGI:7715159
• Synonyms: Peli3^-, Peli3^1f
• Gene: Peli3 Location: Chr19:4979745-4993155 bp, - strand Genetic Position: Chr19, 4.17 cM
• Alliance: Peli3^tm1.1Shp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:353497
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted 117 bp upstream of exon 2 and an FRT site, loxP site, neomycin selection cassette, FRT site, and loxP site were inserted 304 bp downstream of exon 2. Exon 2 and the neomycin selection cassette were deleted via cre-mediated recombination. (J:353497)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Peli3 Mutation: 24 strains or lines available

References

• Original: J:353497 Lee J, et al., Peli3 ablation ameliorates acetaminophen-induced liver injury through inhibition of GSK3beta phosphorylation and mitochondrial translocation. Exp Mol Med. 2023 Jun;55(6):1218-1231
• All: 1 reference(s)