Rigi^tm1.1Ronz
Targeted Allele Detail

Summary

• Symbol: Rigi^tm1.1Ronz
• Name: RNA sensor RIG-I; targeted mutation 1.1, Rongbin Zhou
• MGI ID: MGI:7715130
• Synonyms: Ddx58^fl
• Gene: Rigi Location: Chr4:40203773-40239828 bp, - strand Genetic Position: Chr4, 20.24 cM
• Alliance: Rigi^tm1.1Ronz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282422
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT-flanked neomycin resistance cassette and a second loxP site were inserted downstream of exon 3. The neomycin selection cassette was removed via cre-mediated recombination, leaving exon 3 floxed. (J:282422)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rigi Mutation: 54 strains or lines available

References

• Original: J:282422 Liu L, et al., Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling. Nat Immunol. 2019 Dec;20(12):1681-1691
• All: 1 reference(s)